Understanding Syringe Defects in Fill-Finish: Causes and Prevention Using a Mechanical Baseline
How mechanical shock, pressure, and transport instability create intermittent syringe defects in fill-finish lines Syringe defects in pharmaceutical fill-finish lines rarely occur in a predictable way. A line can operate at nominal speed for hours before a syringe suddenly cracks, breaks, or becomes damaged during transport. When this happens, teams investigate machine settings, glass quality, […]
Lightweight Cans Are Reducing Your Margin for Error
As lightweighting reduces material thickness, cans become more sensitive to variation during seaming and handling. Small deviations that once had little impact can now increase the risk of deformation, defects, and hidden damage across production lines.
If you want a shorter version for stricter CMS limits, use this:
Lightweighting makes cans more sensitive to variation during seaming and handling, increasing the risk of defects, deformation, and hidden damage.
Container Closure Integrity Assurance: Building Reliable Product Protection for Sterile Products
Assuring container closure integrity (CCI) for an injectable product presentation is a governing principle that must be systemically applied during design, development , manufacturing, distribution and use of a sterile product in order to secure product’s SISPQ (Safety, Identity, Strength, Potency, and Quality) at all times. Injectable drugs must be manufactured to be sterile, and […]
Preventing Sterile Vial Glass Breakage: From Cause to Solution
Sterile glass vial breakage remains one of the most persistent challenges in pharmaceutical manufacturing. Every broken vial means wasted product, downtime, and higher costs, while also raising patient safety concerns. Breakage can stem from mechanical impact, thermal stress, or inherent material defects. The good news: with the right combination of equipment upgrades, material selection, handling […]
Container Closure Integrity – Challenge for Injectables
For injectable products, assuring the integrity of the container closure system (CCS) and container closure integrity is fundamental to safeguarding product quality and patient safety over the entire shelf life. Developing an inherently robust CCS is an iterative process—guided by an understanding of product stability, manufacturing methods, and anticipated distribution and storage conditions. Product protection […]
Pharma Production Line Optimization Reduces Downtime By 49% For Sanofi
It’s usually the small changes that lead to big results and pharma giant Sanofi proved this with its pharma production line optimization project. The company’s use of SmartSkin technology for this project at their Waterford plant in Ireland resulted in a massive reduction in downtime and an improvement in yield. Here’s what Sanofi did. Production […]