The 2024 ISPE Annual Meeting & Expo is poised to herald a transformative era in pharmaceutical science and manufacturing. The increasing impact of new technology, treatment modalities and digitalization such as artificial intelligence (AI) and machine learning (ML) in the pharmaceutical industry has sparked interest in many areas of development and CMC. More than ever, an emphasis on cross discipline collaboration is needed for these groundbreaking technologies to be implemented and accepted worldwide. This year’s event also seeks to illuminate their profound impact on organizational readiness and the workforce of the future. By fostering global discussions centered on excellence, modernization, and harmonization, we aim to prepare pharma professionals for the challenges and opportunities of an evolving industry landscape.